Really the injectors should be changed when thier flow rate is exceeded. On a tech tool or OBD11 reader you should be able to see the IPW and IDC which are INjector Pulse Width and Injector Duty Cycle. When the duty cycle exceeds a value ( 90% in my book) they should be upgraded. Common sense will guide you mostly as to when ex. ( Nitrous if dry shot, supercharging, turbocharging) will need the ability for the injector to flow more fuel during the same millisecond opening interval. I could see an extreme N/A engine build utilizing larger injectors as well, especially with heads and cam packages that flow gobs of air and bumped compression ratios.